Chemotherapy Regimens and Protocols
A protocol document also includes:
- background to the trial
- objectives, design, methodology and organisation
- trial type (controlled, uncontrolled, randomised)
- inclusion criteria (who can participate)
- exclusion criteria (who cannot participate)
- success criteria (what determines treatment has worked)
- safety concerns
- length of the study.
- study administrators and researchers
You have the right to ask for a copy of your child’s complete regimen. You should be given a copy of the complete protocol before signing consent to enrol your child in a clinical trial.
Doses of chemotherapy are usually based on your child’s weight or body surface area (BSA – calculated from weight and height and measured in meters squared (M2). Height and/or weight may be measured before each cycle, so doses may vary throughout treatment.
The following drugs are used in different combinations to treat retinoblastoma, with varying degrees of efficiency. Most of these drugs are used when VEC (see below) has failed, or for extraocular or trilateral retinoblastoma.